Some Metabolic Effects of Sodium Nitroprusside in Man
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چکیده
منابع مشابه
Some metabolic effects of sodium nitroprusside in man.
The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B(12) tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions t...
متن کاملSome physiological and metabolic effects of sodium nitroprusside and cyanide in the dog.
The cardiovascular and acid-base changes following equivalent i.v. bolus doses of sodium nitroprusside (SNP) and potassium cyanide (KCN) have been studied in two groups of anaesthetized dogs. In a third group, the metabolic changes produced by i.v. infusion of SNP 1.5 mg kg-1 at a constant rate over 1 h have been studied. In contrast to a decrease in arterial pressure following SNP, hypertensio...
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In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. Nitroprusside (15 patients) was associated with a s...
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1. The effects of graded intravenous infusions of sodium nitroprusside on resting blood pressure and heart rate and on the reflex changes in these variables evoked by a standardized Valsalva manoeuvre were studied in six normal subjects. The effects of nitroprusskle on the above variables were also studied after pretreatment with captopril, to allow assessment of the role of angiotensin 11. 2. ...
متن کاملCyanide and thiocyanate concentrations following sodium nitroprusside infusion in man.
Twenty-six patients, receiving an infusion of sodium nitroprusside (SNP) during surgery, had considerable increases in both red cell and plasma cyanide concentration, but only small changes in plasma thiocyanate concentration. There was a linear relationship between both plasma and RBC cyanide concentrations and the total dose of SNP. The expired cyanide concentration followed the changes in th...
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ژورنال
عنوان ژورنال: BMJ
سال: 1974
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5911.140